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General information on the status of hyperthermia
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  2. Local hyperthermia combined with radiotherapy and-/or chemotherapy: recent advances and promises for the future. Datta NR, Ordóñez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, Marder D, Puric E, Bodis S. Cancer Treat Rev. 2015 Nov;41(9):742-53. doi: 10.1016/j.ctrv.2015.05.009. Epub 2015 May 27. Review.

  3. Hyperthermie, Bundesauschussstudie vom 5.6. 2005
    Biological rationales and clinical applications of temperature controlled hyperthermia--implications for multimodal cancer treatments.
    Schildkopf P, Ott OJ, Frey B, Wadepohl M, Sauer R, Fietkau R, Gaipl US.
    Curr Med Chem. 2010;17(27):3045-57. Review.

  4. Forgoing Conventional Cancer Treatments for Alternative Medicine Increases Risk of Death September 12, 2017, by NCI Staff https://www.cancer.gov/news-events/cancer-currents-blog/2017/alternative-medicine-cancer-survival

  5. Franconi C, Raganella L, Tiberio CA. Low-frequency RF hyperthermia: IV--A 27 MHz hybrid applicator for localized deep tumor heating. (1991) IEEE Trans Biomed Eng. Mar;38(3):287-93.

  6. Ghadjar. Int. J. Hyperthermia. 2015. in press.

  7. Jo S, Sugahara T, Yamamoto I: Clinical response of hyperthermia using heating equipment thermotron-RF8 in Japan, Biomed Eng. Appl. Basis Comm. 1994, 6:340-362

  8. Van der Zee J, Vujaskovic Z, Kondo M, Sugahara T. The Kadota Fund International Forum 2004--clinical group consensus. Int J Hyperthermia. 2008;24:111–22.

  9. Muratkhozhaev NK, Svetitsky PV, Kochegarov AA. et al. Hyperthermia in therapy of cancer patients. Med Radiol (Russian) 1987;32:30–36.

  10. NIH 2017 Foregoing Conventional Cancer Treatments 12 September 2017 https://www.ncbi.nlm.nih.gov/pubmedhealth/behindtheheadlines/news/2017-08-16-alternative-cancer-therapies-may-increase-your-risk-of-death/

  11. Sahinbas H, M. Rosch, M. Demiray; Temperature measurements in a capacitive system of deep loco-regional hyperthermia; Electromagnetic Biology and Medicine; ISSN: 1536-8378 (Print) 1536-8386 (Online) Journal; DOI: 10.1080/15368378.2017.130722; Published online: 27 Apr 2017.

  12. Savchenco NE, Zhakov IG, Fradkin SZ. et al. The use of hyperthermia in oncology. Med Radiol (Russian) 1987;32:19–24.

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  16. Stewart, F.A.Mount Vernon Hospital, Northwood (UK). Gray Lab The effects of hyperthermia and ionizing radiation on bladder, skin and an experimental tumour in mice Thesis/Dissertation, Oct 1978; 301 p; British Library, Boston Spa, Wetherby, West Yorks. No. D26538/79; Thesis (Ph.D.)

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Hyperthermia in combination with radiotherapy
  1. Abe M, Hiraoka M, Takahashi M, Egawa S, Matsuda C, Onoyama Y, Morita K, Kakehi M, Sugahara T. Multi-institutional studies on hyperthermia using an 8-MHz radiofrequency capacitive heating device (Thermotron RF-8) in combination with radiation for cancer therapy. Cancer 1986; 58 (8): 1589-95

  2. Berdov B.A, Kurpeshev O.K, Mardinsky Yu.S. Influence of Hyperthermia and Hyperglycemia on Efficiency Radiation Therapy for Oncological Patients. Russian Journal of Oncology 1996;xx:xx.

  3. Berdov B A, Menteshashvili G Z. Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. IntJ Hyperthermia 1990;6(5):881–90.

  4. Bergs JWJ, Franken NAP, Haveman J, Geijsen ED, Crezee J, van Bree C. Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application. Int J Hyperthermia. 2007; 23:329–41.

  5. Bruggmoser, G., Bauchowitz, S., Canters, R., Crezee, H., Ehmann, M., Gellermann, J., Lamprecht, U., Lomax, N., Messmer, M. B., Ott, O., Abdel-Rahman, S., Schmidt, M., Sauer, R., Thomsen, A., Wessalowski, R., van Rhoon, G. The Guideline for the clinical application, documentation and analysis of clinical studies for regional deep hyperthermia, Strahlentherapie und Onkologie, Vol. 188, No. 2, p.198-211. ISSN 1439-099X, Cancer Center Amsterdam, Radiotherapy 2012

  6. Burgman P, Ouyang H, Peterson S, Chen DJ, Li GC. Heat inactivation of Ku autoantigen: possible role in hyperthermic radiosensitization. Cancer Res. 1997; 57:2847–50. Cancer. Jul 1;60(1):128-35

  7. Cochrane Systematic Review 2009 De Haas-Kock DFM, Buijsen J, Pijls-Johannesma M, Lutgens L, Lammering G, Mastrigt GAPGV, De Ruysscher DKM, Lambin P, van der Zee J. Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD006269. DOI: 10.1002/14651858.CD006269.pub2.

  8. Choynzonov E.L., Mukhamedov M.R., Startseva Z.A., Spivakova I.O., Cheremisina O.V., Vasilyev N.V., Gribova O.V. Combined modality treatment including local hyperthermia in patients with locally-advanced laryngeal and laryngopharyngeal cancer Siberian journal of oncology. 2015;(6):13-18. (In Russ.)

  9. Choynzonov Е.L., Startseva Z.А., Mukhamedov М.R., Spivakova I.О., Cheremisina О.V., Gribova О.V., Kulbakin D.Е., Surkova P.V. Local hyperthermia in combined modality treatment of laryngeal and laryngopharyngeal cancer Siberian journal of oncology. 2014;(5):5-9. (In Russ.)

  10. Egawa S, Tsukiyama I, Watanabe N, Ohno Y, Morita K, et al. A randomised trial of hyperthermia and radiation versus radiation alone for superficially located cancers. J Jpn Soc Ther Radiol Oncol 1989; 1:135-40

  11. Falk MH, Issels RD. Hyperthermia in oncology. Int J Hyperthermia. 2001; 17:1–18.

  12. Feyerabend, T, Wiedemann GJ, Jäger B, Vesely H, Mahlmann B, Richter E. Local hyperthermia, radiation, and chemotherapy in recurrent breast cancer is feasible and effective except for inflammatory disease. International journal of radiation oncology, biology, physics; 2001; 49 (5): 1317-25

  13. Fuwa N, Morita K, Kimura C. et al. Combined treatment of radio-therapy and local hyperthermia using 8MHz RF-wave for advanced carcinoma of the breast. In: Onoyama Y, ed. Hyperthermic Oncology 86 in Japan. Proceedings of the 3rd annual meeting of the Japanese Societey of Hyperthermic Oncology. 1986:337–338.

  14. Goldobenko GV, Durnov LA, Knysh VI. et al. Experience of the use of thermoradiotherapy of malignant tumors. Med Radiol (Russian) 1987; 32:36–37.

  15. Hager ED, Dziambor H, Höhmann D. et al. Deep hyperthermia with radiofrequencies in patients with liver metastases from colorectal cancer. Anticancer Research. 1999;19:3403–3408.

  16. Harima Y, Nagata K, Harima K. et al. Bax and Bcl-2 protein expression following radiation therapy versus radiation plus thermotherapy in stage IIIB cervical carcinoma. Cancer. 2000;88:132–138.

  17. Hiraoka M, Jo S, Akuta K, Nishimura Y, Takahashi M, Abe M. (1987) Radiofrequency capacitive hyperthermia for deep-seated tumors. II. Effects of thermoradiotherapy.

  18. Hiraoka M, Jo S, Dodo Y. et al. Clinical results of radiofrequency hayperthermia combined with radiation in the treatment of radioresistant cancers. Cancer. 1984; 54:2898–2904.

  19. Hiraoka M, Masunaga S, Nishimura Y. et al. Regional hyperthermia combined with radiotherapy in the treatment of lung cancer. Int J Radiat Oncol Biol Phys. 1992; 22:1009–1014.

  20. Hornbach NB, Shupe RE, Shidnia H. et al. Advanced stage IIIB cancer of the cervix treatment by hyperthermia and radiation. Gynecol Oncol. 1986;23:160–167.

  21. Horsman MR, Overgaard J. Hyperthermia: a potent enhancer of radiotherapy. Clin Oncol. 2007;19:418–26.

  22. Ikeda H, Tanaka M, Matsuo R, Fukuda H, Yamada R, Yamamoto I. (2001) Development of a new heating needle for interstitial hyperthermia compatible with interstitial radiotherapy. Radiat Med. Nov-Dec;19(6):285-9.

  23. Lee CK, Song CW, Rhee JG, Foy JA, Levitt SH (1995) Clinical experience using 8 MHz radiofrequency capacitive hyperthermia in combination with radiotherapy: results of a phase I/II study. Int J Radiat Oncol Biol Phys. Jun 15;32(3):733-45.

  24. Masunaga S, Hiraooka M, Takahashi M. et al. Clinical results of thermradiotherapy for locally advanced and/or resurrent breast cancer—comparison of results with radiotherapy alone. Int J Hyperthermia. 1990;6:487–497.

  25. Jung Kyung Kim; Bibin Prasad; Suzy Kim Kakehi M, Ueda K, Mukomojima M. et al. Multi-institutional clinical studies on hyperthermia combined with radiotherapy or chemotherapy in advanced cancer of deep-seated organs. Int J Hyperthermia. 1996; 6(4):719–740.

  26. Kim BS, Chung HC, Seong JS, Suh CO, Kim GE (1992) Phase II trial for combined external radiotherapy and hyperthermia for unresectable hepatoma. Cancer Chemother Pharmacol. 31 Suppl:S119-27. PMID: 1281042

  27. Kim W, MS Kim, H Kim, E Lee, J Jeong Role of HIF-1α in response of tumors to a combination of hyperthermia and radiation in vivo https://doi.org/10.1080/02656736.2017.1335440

  28. Lepock JR. Role of nuclear protein denaturation and aggregation in thermal radiosensitization. Int J Hyperthermia. 2004;20:115–30.

  29. Lindholm CE, Kjellen E, Nilsson P, Hertzman S: Microwave-induced hyperthermia and radiotherapy in human superficial tumors, Int. J. Hyperthermia, 1987, 3:393-411

  30. Novikov V.A., O. V. Gribova, R. V. Vasiljev, A. I. Ryabova, E. L. Choinzonov, V. I. Shtin, P. V. Surkova, Zh. A. Starceva, and O. G. Shilova Local Hyperthermia in the Treatment of Sinonasal Carcinoma Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk State University of Control Systems and Radioelectronics, Tomsk, 634050 Russia

  31. Stewart FA, Denekamp J. The therapeutic advantage of combined heat and X-rays on a mouse fibrosarcoma. Br J Radiol 1978; 51:307-316

  32. Temperature mapping and thermal dose calculation in combined radiation therapy and 13.56 MHz radiofrequency hyperthermia for tumor treatment Proceedings Volume 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI; 1004718 (2017); doi: 10.1117/12.2253163

  33. van der Zee J, Gonzalez Gonzalez D, van Rhoon G C, van Dijk J D, van Putten W L, Hart A A. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet 2000;355(9210):1119–25.

  34. van der Zee J1, González González D, van Rhoon GC, van Dijk JD, van Putten WL, Hart AA.Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet. 2000 Apr 1;355(9210):1119-25.

  35. Uozumi H, Baba Y, Yasunaga T, Ookura M, Takada C, Ueno S, Hoshiko N, Miyao M, Hatanaka Y, Takahashi M: Clinical evaluation of combined hyperthermia and radiation therapy of superfici malignant tumors, in: Hyperthermic Oncology’86 in Japan, Proceedings of the 3rd annual meeting of the Japanese Society of Hyperthermic Oncology, (Ed: Onoyama Y) 1986, pp.311-312
Hyperthermia in combination with chemotherapy
  1. Dies ist die bislang umfangreichste Studie (Phase 3 randomisiert, prospektiv) in der Hyperthermie in Kombination mit ausschließlich Chemotherapeutika:
    Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study.Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem BC, Abdel-Rahman S, Daugaard S, Salat C, Wendtner CM, Vujaskovic Z, Wessalowski R, Jauch KW, Dürr HR, Ploner F, Baur-Melnyk A, Mansmann U, Hiddemann W, Blay JY, Hohenberger P; European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC-STBSG); European Society for Hyperthermic Oncology (ESHO). Lancet Oncol. 2010 Jun;11(6):561-70. doi: 10.1016/S1470-2045(10)70071-1. Epub 2010 Apr 29.

  2. JAMA Oncol. 2018 Feb 15. doi: 10.1001/jamaoncol.2017.4996. Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial.
    Issels RD1, Lindner LH1, Verweij J2, Wessalowski R3, Reichardt P4, Wust P5, Ghadjar P5, Hohenberger P6, Angele M7, Salat C1, Vujaskovic Z8, Daugaard S9, Mella O10, Mansmann U11, Dürr HR12, Knösel T13, Abdel-Rahman S1, Schmidt M14, Hiddemann W1, Jauch KW7, Belka C15, Gronchi A16; European Organization for the Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group and the European Society for Hyperthermic Oncology.

  3. Colombo R, da Pozzo LF, Lev A, Freschi M, Gallus G, Rigatti P (1996) Neoadjuvant combined microwave induced local hyperthermia and topical chemotherapy versus chemotherapy alone for superficial bladder cancer. The Journal of Urology 1996; 155:1227-1232

  4. Colombo R, Da Pozzo LF, Salonia A, Rigatti P, Leib Z, Baniel J, et al. Multicentric study comparing intravesical chemotherapy alone and with local microwave hyperthermia for prophylaxis of recurrence of superficial transitional cell carcinoma. J Clin Oncol. 2003; 21:4270–6.

  5. Colombo R, Salonia A, Leib Z, Pavone-Macaluso M, Engelstein D. Long-term outcomes of a randomized controlled trial comparing thermochemotherapy with mitomycin-C alone as adjuvant treatment for non-muscle-invasive bladder cancer (NMIBC). BJU Int. 2011; 107:912–8.

  6. Feyerabend, T, Wiedemann GJ, Jäger B, Vesely H, Mahlmann B, Richter E. Local hyperthermia, radiation, and chemotherapy in recurrent breast cancer is feasible and effective except for inflammatory disease. International journal of radiation oncology, biology, physics; 2001; 49 (5): 1317-25

  7. Hoshina H, Takagi R, Tsurumaki H, et al. Clinical result of thermochemoradiotherapy for advanced head and neck cancer. Gan To Kagaku Ryoho. 2001;28:331–6.

  8. Jeeyun Lee, MD, PhD, Se Hoon Park, MD, Joon Oh Park, MD, Young Suk Park, MD, Jeong Il Yu, MD, Hee Chul Park, MD, PhD, Doo Ho Choi, MD, PhD, Jae Myoung Noh, MD, Dongryul Oh, MD, Jun Su Park, MD, Ji Hyun Chang, MD, Seung Tae Kim, MD, Ho Yeong Lim, MD, PhD, Won Ki Kang, MD Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer Radiat Oncol J 2016;34(1):34-44 http://dx.doi.org/10.3857/roj.2016.34.1.34 pISSN 2234-1900, eISSN 2234-3156

  9. Jung Kyung Kim; Bibin Prasad; Suzy Kim Kakehi M, Ueda K, Mukomojima M. et al. Multi-institutional clinical studies on hyperthermia combined with radiotherapy or chemotherapy in advanced cancer of deep-seated organs. Int J Hyperthermia. 1996; 6(4):719–740.

  10. Maluta S, Schaffer M, Pioli F, Dall’oglio S, Pasetto S, Schaffer PM, Weber B, Giri MG (2011) Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer: an open-label comparative cohort trial. Strahlenther Onkol 187(10):619–625

  11. Mi D-H, Li Z, Yang K-H, Cao N, Lethaby A, Tian J-H, Santesso N, Ma B, Chen Y-L, Liu Y-L (2013) Surgery combined with intraoperative hyperthermic intraperitoneal chemotherapy (IHIC) for gastric cancer: a systematic review and meta-analysis of randomised controlled trials. Int J Hyperth 29(2):156–167

  12. Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K. (2015) A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study. Cancer Med. Jun;4(6):834-43. doi: 10.1002/cam4.431. Epub 2015 Feb 9.

  13. Mulier S, Claes J-P, Dierieck V, Amiel J-O, Pahaut J-P, Marcelis L, et al. Survival benefit of adding Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) at the different time-points of treatment of ovarian cancer: review of evidence. Curr Pharm Des. 2012;18:3793–803
Hyperthermia as a building block in immunotherapy
  1. Editorial: Radiation and the Immune System: Current Knowledge and Future Perspectives.Lumniczky K, Candéias SM, Gaipl US, Frey B. Front Immunol. 2018 Jan 23;8:1933. doi: 10.3389/fimmu.2017.01933. eCollection 2017. No abstract available.

  2. The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia. Finkel P, Frey B, Mayer F, Bösl K, Werthmöller N, Mackensen A, Gaipl US, Ullrich E. Oncoimmunology. 2016 Jun 7;5(6):e1101206. doi: 10.1080/2162402X.2015.1101206. eCollection 2016 Jun.

  3. Old and new facts about hyperthermia-induced modulations of the immune system. Frey B, Weiss EM, Rubner Y, Wunderlich R, Ott OJ, Sauer R, Fietkau R, Gaipl US. Int J Hyperthermia. 2012;28(6):528-42. doi: 10.3109/02656736.2012.677933. Epub 2012 Jun 12. Review.

  4. Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages. Schildkopf P, Frey B, Ott OJ, Rubner Y, Multhoff G, Sauer R, Fietkau R, Gaipl US. Radiother Oncol. 2011 Oct;101(1):109-15. doi: 10.1016/j.radonc.2011.05.056. Epub 2011 Jun 23.

  5. Biological rationales and clinical applications of temperature controlled hyperthermia--implications for multimodal cancer treatments. Schildkopf P, Ott OJ, Frey B, Wadepohl M, Sauer R, Fietkau R, Gaipl US. Curr Med Chem. 2010;17(27):3045-57. Review.

  6. A review of immune therapy in cancer and a question: can thermal therapy increase tumor response? Joan M. C. Bull To cite this article: Joan M. C. Bull (2017): A review of immune therapy in cancer and a question: can thermal therapy increase tumor response?, International Journal of Hyperthermia

  7. Fever and the thermal regulation of immunity: the immune system feels the heat. Evans SS, Repasky EA, Fisher DT. Nat Rev Immunol. 2015 Jun;15(6):335-49. doi: 10.1038/nri3843. Epub 2015 May 15. Review.

  8. Temperature matters! And why it should matter to tumor immunologists. Repasky EA, Evans SS, Dewhirst MW. Cancer Immunol Res. 2013 Oct;1(4):210-6. doi: 10.1158/2326-6066.CIR-13-0118. Review.

  9. Issels RD (2008) Hyperthermia adds to chemother¬apy. Eur J Cancer 44(17):2546–2554
Hyperthermia and cell behavior
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  2. Adachi S, Kokura S, Okayama T, et al. Effect of hyperthermia combined with gemcitabine on apoptotic cell death in cultured human pancreatic cancer cell lines. Int J Hyperthermia 2009; 25:210–19 Australas Radiol 1996;40(3):298–305

  3. Bergs JWJ, Krawczyk PM, Borovski T, ten Cate R, Rodermond HM, Stap J, et al. Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining. DNA Repair. 2012; 12:38–45.

  4. Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, et al. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010;107:3034–9.

  5. Dube DK, Seal G, Loeb LA. Differential heat sensitivity of mammalian DNA polymerases. Biochem Biophys Res Commun. 1977; 76:483–7.

  6. Genet SC, Fujii Y, Maeda J, Kaneko M, Genet MD, Miyagawa K, et al. Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner. J Cell Physiol. 2013;228:1473–81.
  7. Hugo H, Ackland ML, Blick T, et al. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol. 2007;213:374–83.

  8. Hut HM, Kampinga HH, Sibon OC. Hsp70 protects mitotic cells against heat-induced centrosome damage and division abnormalities. Mol Biol Cell. 2005;16:3776–85.

  9. Ihara M, Suwa A, Komatsu K, Shimasaki T, Okaichi K, Hendrickson EA, et al. Heat sensitivity of double-stranded DNA-dependent protein kinase (DNA-PK) activity. Int J Radiat Biol. 1999;75:253–8.

  10. Ihara M, Takeshita S, Okaichi K, Okumura Y, Ohnishi T. Heat exposure enhances radiosensitivity by depressing DNA-PK kinase activity during double strand break repair. Int J Hyperthermia. 2014;30:102–9.

  11. Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science. 2003;300:1542–8.

  12. Kondo M, Oyamada H, Yoshikawa T. Therapeutic effects of chemoembolization using degradable starch microspheres and regional hyperthermia on unresectable hepatocellular carcinoma. In: Matsuda T, ed. Cancer treatment by hyperthermia and drugs. London/Washington DC: Taylor & Francis. 1993:317–327.

  13. Jones RM, Kotsantis P, Stewart GS, Groth P, Petermann E. BRCA2 and RAD51 promote double-strand break formation and cell death in response to gemcitabine. Mol Cancer Ther. 2014;13:2412–21.

  14. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119:1420–8.

  15. Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem. 2010;79:181–211.

  16. Lim CU, Zhang Y, Fox MH. Cell cycle dependent apoptosis and cell cycle blocks induced by hyperthermia in HL-60 cells. Int J Hyperthermia. 2006;22:77–91

  17. Luchetti F, Canonico B, Della Felice M, Burattini S, Battistelli M, Papa S, et al. Hyperthermia triggers apoptosis and affects cell adhesiveness in human neuroblastoma cells. Histol Histopathol. 2003;18:1041–52.

  18. Floris M. Watchers, John W.G. van Putten, Jan G. Maring, Selective targeting of homologous DNA recombination repair by gemcitabine. Int J Radiat Oncol Biol Phys. 2003;57:553–62.

  19. Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, et al. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proc Natl Acad Sci U S A. 2011;108:9851–6.

  20. Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3’ kinase/AKT pathways. Oncogene. 2005;24:7443–54.

  21. Lee J-H, Paull TT. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science. 2004;304:93–6.
  22. Matsumoto Y, Suzuki N, Sakai K, Morimatsu A, Hirano K, Murofushi H. A possible mechanism for hyperthermic radiosensitization mediated through hyperthermic lability of Ku subunits in DNA-dependent protein kinase. Biochem Biophys Res Commun. 1997;234:568–72.

  23. Meyn RE, et al. Thermal enhancement of DNA damage in mammalian cells treated with cisdiamminedichloroplatinum(II). Cancer Res. 1980;40:1136–9.

  24. Min C, Eddy SF, Sherr DH, et al. NF-kappaB and epithelial to mesenchymal transition of cancer. J Cell Biochem. 2008;104:733–44.

  25. Mondovi B, Strom R, Rotilio G, Agro AF, Cavalliere R, Rossi FA. The biochemical mechanism of selective heat sensitivity of cancer cells. Eur J Cancer. 1969;5:129–36.
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  27. Ota I, et al. Transfection with a mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2000;47:495–501.
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  29. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem. 1998;273:5858–68.

  30. Roti Roti JL. Cellular responses to hyperthermia (40–46 degrees C): cell killing and molecular events. Int J Hyperthermia. 2008; 24:3–15.

  31. Nagashima K, Takagi R, Hoshina H. Effect of local hyperthermia on metastases in oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2002;31:84–9.

  32. Sapareto SA, Raaphorst GP, Dewey WC. Cell killing and the sequencing of hyperthermia and radiation. Int J Radiat Oncol Biol Phys. 1979;5:343–7

  33. Takahashi A, Mori E, Ohnishi T. Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with γH2AX in the nucleus after heat treatment. Annals of Cancer Research and Therapy. 2007;15:50–3.

  34. Takahashi A, Mori E, Somakos GI, Ohnishi K, Ohnishi T. Heat induces γH2AX foci formation in mammalian cells. Mutat Res. 2008;656:88–92.

  35. Raoof M, Zhu C, Cisneros BT, Liu H, Corr SJ, Wilson LJ, et al. Hyperthermia inhibits recombination repair of gemcitabine-stalled replication forks. J Natl Cancer Inst. 2014;106:dju183.

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  39. Warters RL, Stone OL. The effects of hyperthermia on DNA replication in HeLa cells. Radiat Res. 1983; 93:71–84.

  40. Westra A, Dewey WC. Variation in sensitivity to heat shock during the cell-cycle of Chinese hamster cells in vitro. Int J Radiat Biol Relat Stud Phys Chem Med. 1971;19:467–77.

  41. Vidair CA, Doxsey SJ, Dewey WC. Heat shock alters centrosome organization leading to mitotic dysfunction and cell death. J Cell Physiol. 1993;154:443–55.

  42. Wachters FM, van Putten JWG, Maring JG, Zdzienicka MZ, Groen HJM, Kampinga HH. Selective targeting of homologous DNA recombination repair by gemcitabine. Int J Radiat Oncol Biol Phys. 2003;57:553–62.

  43. Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871–90.

  44. Yumoto Y, Jinno K, Tokuyama K, Wada T, Kobashi H, Okamoto T, Toki H, Inatsuki S, Hara K, Moriwaki S, et al. (1991) Trans-catheter hepatic arterial injection of lipiodol soluble anti-cancer agent SMANCS and ADR suspension in lipiodol combined with arterial embolization and local hyperthermia for treatment of hepatocellular carcinoma. Int J Hyperthermia. Jan-Feb;7(1):7-17.

  45. Hypofractionated Irradiation Has Immune Stimulatory Potential and Induces a Timely Restricted Infiltration of Immune Cells in Colon Cancer Tumors. Frey B, Rückert M, Weber J, Mayr X, Derer A, Lotter M, Bert C, Rödel F, Fietkau R, Gaipl US. Front Immunol. 2017 Mar 8;8:231. doi: 10.3389/fimmu.2017.00231. eCollection 2017.

  46. Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells. Mantel F, Frey B, Haslinger S, Schildkopf P, Sieber R, Ott OJ, Lödermann B, Rödel F, Sauer R, Fietkau R, Gaipl US. Strahlenther Onkol. 2010 Nov;186(11):587-99. doi: 10.1007/s00066-010-2154-x. Epub 2010 Nov 8.

  47. Application of hyperthermia in addition to ionizing irradiation fosters necrotic cell death and HMGB1 release of colorectal tumor cells. Schildkopf P, Frey B, Mantel F, Ott OJ, Weiss EM, Sieber R, Janko C, Sauer R, Fietkau R, Gaipl US. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1014-20. doi: 10.1016/j.bbrc.2009.12.008. Epub 2009 Dec 5.

  48. Hyperthermia in combination with X-irradiation induces inflammatory forms of cell death. Schildkopf P, Holmer R, Sieber R, Ott OJ, Janko C, Mantel F, Frey B, Fietkau R, Gaipl US. Autoimmunity. 2009 May;42(4):311-3.

  49. Fever-range whole body thermotherapy combined with oxaliplatin: a curative regimen in a pre-clinical breast cancer model. Rowe RW, Strebel FR, Proett JM, Deng W, Chan D, He G, Siddik Z, Bull JM. Int J Hyperthermia. 2010;26(6):565-76. doi: 10.3109/02656736.2010.483635.

  50. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-alpha: a description of a phase I-II protocol. Bull JM, Scott GL, Strebel FR, Nagle VL, Oliver D, Redwine M, Rowe RW, Ahn CW, Koch SM. Int J Hyperthermia. 2008 Dec;24(8):649-62. doi: 10.1080/02656730802104740.

  51. Effector CD8+ T cell IFN-γ production and cytotoxicity are enhanced by mild hyperthermia. Mace TA, Zhong L, Kokolus KM, Repasky EA. Int J Hyperthermia. 2012;28(1):9-18. doi: 10.3109/02656736.2011.616182. Combination of ionising irradiation and hyperthermia activates programmed apoptotic and necrotic cell death pathways in human colorectal carcinoma cells. Mantel F, Frey B, Haslinger S, Schildkopf P, Sieber R, Ott OJ, Lödermann B, Rödel F, Sauer R, Fietkau R, Gaipl US. Strahlenther Onkol. 2010 Nov;186(11):587-99. doi: 10.1007/s00066-010-2154-x. Epub 2010 Nov 8.
Hyperthermia in breast cancer
  1. Ellen Jones et al; Randomized trial for hyperthermia and radiation for superficial tumors; in: Journal of Clin.Oncology Vol.23.;13, 2005

  2. Markus Notter, Helmut Piazena & Peter Vaupel (2016): Hypofractionated re-irradiation of large-sized recurrent breast cancer with thermography-controlled, contactfree water- filtered infra-red-A hyperthermia: a retrospective study of 73 patients;in: International Journal of Hyperthermia, 2016 DOI: 10.1080/02656736.2016.1235731

  3. Feyerabend, T, Wiedemann GJ, Jäger B, Vesely H, Mahlmann B, Richter E. Local hyperthermia, radiation, and chemotherapy in recurrent breast cancer is feasible and effective except for inflammatory disease. International journal of radiation oncology, biology, physics; 2001; 49 (5): 1317-25

  4. Feyerabend, T, Wiedemann GJ, Jäger B, Vesely H, Mahlmann B, Richter E. Local hyperthermia, radiation, and chemotherapy in recurrent breast cancer is feasible and effective except for inflammatory disease. International journal of radiation oncology, biology, physics; 2001; 49 (5): 1317-25

  5. Fuwa N, Morita K, Kimura C. et al. Combined treatment of radio-therapy and local hyperthermia using 8MHz RF-wave for advanced carcinoma of the breast. In: Onoyama Y, ed. Hyperthermic Oncology 86 in Japan. Proceedings of the 3rd annual meeting of the Japanese Societey of Hyperthermic Oncology. 1986:337–338.

  6. Masunaga S, Hiraooka M, Takahashi M. et al. Clinical results of thermradiotherapy for locally advanced and/or resurrent breast cancer—comparison of results with radiotherapy alone. Int J Hyperthermia. 1990;6:487–497.

  7. Perez CA, Kuske RR, Emami B, Fineberg B.: Irradiation alone or combined with hyperthermia in the treatment of recurrent carcinoma of the breast. A nonrandomized comparison. Int J Hyperthermia 1986; 2: 179-87

  8. Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, van der Zee J, et al. Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. Int. J. Radiat. Oncol. Biol. Phys. 1996;35:731–44.
Hyperthermia in bladder cancer
  1. Colombo R, Salonia A, Leib Z, Pavone-Macaluso M, Engelstein D. Long-term outcomes of a randomized controlled trial comparing thermochemotherapy with mitomycin-C alone as adjuvant treatment for non-muscle-invasive bladder cancer (NMIBC). BJU Int. 2011; 107:912–8.

  2. Hyperthermia and radiotherapy in bladder cancer. Snider JW 3rd, Datta NR, Vujaskovic Z. Int J Hyperthermia. 2016 Jun;32(4):398-406. doi: 10.3109/02656736.2016.1150524. Epub 2016 Apr 20. Review.

  3. Is hyperthermia combined with radiotherapy adequate in elderly patients with muscle-invasive bladder cancers? Thermo-radiobiological implications from an audit of initial results. Datta NR, Eberle B, Puric E, Meister A, Marder D, Tim O, Klimov A, Bodis S. Int J Hyperthermia. 2016 Jun;32(4):390-7. doi: 10.3109/02656736.2015.1132340. Epub 2016 Jan 22.

  4. Quadrimodal treatment of high-risk T1 and T2 bladder cancer: transurethral tumor resection followed by concurrent radiochemotherapy and regional deep hyperthermia. Wittlinger M, Rödel CM, Weiss C, Krause SF, Kühn R, Fietkau R, Sauer R, Ott OJ. Radiother Oncol. 2009 Nov;93(2):358-63. doi: 10.1016/j.radonc.2009.09.018.
Hyperthermia in rectal and anal CA
  1. Berdov B A, Menteshashvili G Z. Thermoradiotherapy of patients with locally advanced carcinoma of the rectum. IntJ Hyperthermia 1990;6(5):881–90.

  2. Cochrane Systematic Review 2009 De Haas-Kock DFM, Buijsen J, Pijls-Johannesma M, Lutgens L, Lammering G, Mastrigt GAPGV, De Ruysscher DKM, Lambin P, van der Zee J. Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD006269. DOI: 10.1002/14651858.CD006269.pub2.

  3. Nishimura Y, Hiraoka M, Akuta K. et al. Hyperthermia combined with radiation therapy for primary unresectable and recurrent colorectal cancer. Int J Radiat Oncol Biol Phys. 1992;23:759–768.

  4. Trotter J M, Edis A J, Blackwell J B, Lamb M H, Bayliss E J, Shepherd J M, Cassidy B. Adjuvant VHF therapy in locally recurrent and primary unresectable rectal cancer.

  5. You QS, Wang RZ, Suen GQ, Yan FC, Gao YJ, Cui SR, Zhao JH, Zhao TZ, Ding L. Combination preoperative radiation and endocavitary hyperthermia for rectal cancer: long-term results of 44 patients. Int J Hyperthermia 1993; 9 (1): 19-24

  6. Milani V, Pazos M, Issels RD et al (2008) Radioche¬motherapy in combination with regional hyper¬thermia in preirradiated patients with recurrent rectal cancer. Strahlenther Onkol 184:163–168
Hyperthermia and tumors of the larynx and esophagus
  1. Choynzonov E.L., Mukhamedov M.R., Startseva Z.A., Spivakova I.O., Cheremisina O.V., Vasilyev N.V., Gribova O.V. Combined modality treatment including local hyperthermia in patients with locally-advanced laryngeal and laryngopharyngeal cancer Siberian journal of oncology. 2015;(6):13-18. (In Russ.)

  2. Choynzonov Е.L., Startseva Z.А., Mukhamedov М.R., Spivakova I.О., Cheremisina О.V., Gribova О.V., Kulbakin D.Е., Surkova P.V. Local hyperthermia in combined modality treatment of laryngeal and laryngopharyngeal cancer Siberian journal of oncology. 2014;(5):5-9. (In Russ.)

  3. Kitamura K, Kuwano H, Watanabe M, Nozoe T, Yasuda M, Sumiyoshi K, Saku M, Sugimachi K.J: Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma, Surg Oncol 1995 Sep;60(1):55-58.

  4. Kitamura K, Kuwano H, Watanabe M, Nozoe T, Yasuda M, Sumiyoshi K, Saku M, Sugimachi K.J: Prospective randomized study of hyperthermia combined with chemoradiotherapy for esophageal carcinoma, Surg Oncol 1995 Sep;60(1):55-58.
  5. Sugimachi K, Kitamura K, Baba K. Hyperthermia combined with chemotherapy and irradiation for patients with carcinoma of the oesophagus: a prospective randomized trial. Int J Hyperthermia. 1992;8:289–295.

  6. Sugimachi K, Kuwano H, Ide H et al. Chemotherapy combined with or without hyperthermia for patients with oesophageal carcinoma: a prospective randomized trial. Int J Hyperthermia 1994:4:485-493

  7. Wang J, Li D, Chen N.: Intracavitary microwave hyperthermia combined with external irradiation in the treatment of esophageal cancer. [Article in Chinese], Zhonghua Zhong Liu Za Zhi 1996 Jan;18(1):51-54

  8. Yano T, et al. Hyperthermic enhancement of cis-diamminedichloroplatinum (II)-induced DNA damage in human esophageal cancer transplantable to nude mice. Anticancer Res.1993;13:1989–97.
Hyperthermia in head and neck tumors
  1. A retrospective analysis of patients with head and neck cancer treated with radiation, hyperthermia, and cetuximab: A brief report of outcome. Huilgol NG. J Cancer Res Ther. 2016 Jul-Sep;12(3):1164-1166. doi: 10.4103/0973-1482.194600.

  2. Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: a report of randomized trial. Huilgol NG, Gupta S, Sridhar CR. J Cancer Res Ther. 2010 Oct-Dec;6(4):492-6. doi: 10.4103/0973-1482.77101.

  3. Hoshina H, Takagi R, Tsurumaki H, et al. Clinical result of thermochemoradiotherapy for advanced head and neck cancer. Gan To Kagaku Ryoho. 2001;28:331–6.

  4. Valdagni R, Amichetti M, Pani G. Radical radiation alone versus radical radiation plus microwave hyperthermia for N3 (TNM-UICC) neck nodes: a prospective randomized clinical trial. Int J Radiat Oncol Biol Phys. 1988;15:13–24.
Hyperthermia in brain tumors
  1. Sneed PK, Stauffer PR, McDermott MW, Diederich CJ, Lamborn KR, Prados MD, Chang S, Weaver KA, Spry L, Malec MK, Lamb SA, Voss B, Davis RL, Wara WM, Larson DA, Phillips TL, Gutin PH. Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiforme. Int J Radiat Oncol Biol Phys 1998; 40: 287-95

  2. Hager ED, Dziambor H, App EM. et al. The treatment of patients woth high-grade malignant gliomas with RF-hyperthermia. Proc ASCO. 2003;22(470):118.
Hyperthermia in GIT tumors
  1. Nagata Y, Hiraola M, Nishimura Y. et al. Radiofrequency hyperthermia for advanced gastric cancer. In: Gerner EW, ed. Hyperthermic Oncology. Tucson: Arizona Board of Regents. 1992:407–412.

  2. Shchepotin IB, Evans SR, Chorny V. et al. Intensive pre-operative radiotherapy with local hyperthermia for the treatment of gastric carcinoma. Surg Oncol. 1994;1:37–44.
Hyperthermia and liver tumors / metastases
  1. Combination treatment with transarterial chemoembolization, radiotherapy, and hyperthermia (CERT) for hepatocellular carcinoma with portal vein tumor thrombosis: Final results of a prospective phase II trial. Yu JI, Park HC, Jung SH, Choi C, Shin SW, Cho SK, Sinn DH, Paik YH, Gwak GY, Choi MS, Lee JH, Koh KC, Yoo BC, Sahinbas H, Paik SW. Oncotarget. 2017 Apr 13;8(32):52651-52664. doi: 10.18632/oncotarget.17072. eCollection 2017 Aug 8.

  2. Hager ED, Dziambor H, Höhmann D. et al. Deep hyperthermia with radiofrequencies in patients with liver metastases from colorectal cancer. Anticancer Research. 1999;19:3403–3408.

  3. Hager ED, Dziambor H, Höhmann D. et al. Deep hyperthermia with radiofrequencies in patients with liver metastases from colorectal cancer. Anticancer Research. 1999;19:3403–3408.
Hyperthermia in soft tissue tumors
  1. Hiraoka M, Nishimura Y, Masunaga S. et al. Clinical results of thermoradiotherapy of soft tissue tumors. Int J Hyperthermia. 1995; 11:365–377.

  2. Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem B-C, et al. Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet Oncol. 2010;11:561–70.
Hyperthermia and uterine cancer
  1. van der Zee J1, González González D, van Rhoon GC, van Dijk JD, van Putten WL, Hart AA. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet. 2000 Apr 1;355(9210):1119-25.

  2. De Wit R, van der Zee J, van der Burg ME, Kruit WH, Logmans A, van Rhoon GC, et al. A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix. Br J Cancer. 1999; 80:1387–91.

  3. Franckena M, De Wit R, Ansink AC, Notenboom A, Canters RAM, Fatehi D, et al. Weekly systemic cisplatin plus locoregional hyperthermia: an effective treatment for patients with recurrent cervical carcinoma in a previously irradiated area. Int J Hyperthermia. 2007; 23:443–50.

  4. Hornbach NB, Shupe RE, Shidnia H. et al. Advanced stage IIIB cancer of the cervix treatment by hyperthermia and radiation. Gynecol Oncol. 1986;23:160–167.

  5. Datta NR, Bose AK, Kapoor HK. Thermoradiotherapy in the management of carcinoma cervix (IIIB): a controlled clinical study. Indian Med Gazette. 1987; 121:68–71

  6. Harima Y, Nagata K, Harima K. et al. A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma. Int J Hyperthermia. 2001;17(2):97–105

  7. Heijkoop ST, van Doorn HC, Stalpers LJA, Boere IA, van der Velden J, Franckena M, et al. Results of concurrent chemotherapy and hyperthermia in patients with recurrent cervical cancer after previous chemoradiation. Int J Hyperthermia. 2014;30:6–10.

  8. Rietbroek RC, Schilthuis MS, Bakker PJ, van Dijk JD, Postma AJ, González González D, et al. Phase II trial of weekly locoregional hyperthermia and cisplatin in patients with a previously irradiated recurrent carcinoma of the uterine cervix. Cancer. 1997;79:935–43.

  9. Rietbroek RC, Schiltuis MS, Bakker PM. et al. Phase II trial of weekly locoregional hyperthermia and cisplatin in patients with a previously irradiated recurrent carcinoma of the uterine cervix. Cancer. 1997;79:935–942.
Hyperthermia and lung tumors
  1. Dobrodeev A.Y., Zavyalov A.A., Tuzikov S.А., Startseva Z.A. The first experience of using local hyperthermia in combined modality treatment of operable non-small cell lung cancer Siberian journal of oncology. 2015;(6):52-56. (In Russ.) doi: 10.3109/02656736.2010.521886. Epub 2011 Jan 20.

  2. Hager ED, Krautgartner I, Popa C. et al. Deep Hyperthermia with short waves of patients with advanced stage lung cancer. Hyperthermia in clinical practice. XXII Meeting of the International Clinical Hyperthermia Society. 1999

  3. Hiraoka M, Masunaga S, Nishimura Y. et al. Regional hyperthermia combined with radiotherapy in the treatment of lung cancer. Int J Radiat Oncol Biol Phys. 1992; 22:1009–1014.

  4. Imada H, Nomoto S, Tomimatsu A, Kosaka K, Kusano S, Ostapenko VV, Terashima H: Local control of Nonsmall cell lung cancer by radiotherapy combined with high power hyperthermia using an 8MHz RF capacitive device, Japn. J. Hyperthermic Onco 1999, 15:19-24

  5. Karasawa K. Thermoradiotherapy in the treatment of locally advanced nonsmall cell lung cancer. Int J Radiat Oncol Biol Phys 1994; 30 (5): 1171-7

  6. Vertrees RA, Das GC, Coscio AM, Xie J, Zwischenberger JB, Boor PJ. A mechanism of hyperthermia-induced apoptosis in ras-transformed lung cells. Mol Carcinog. 2005;44:111–21.
Hyperthermia and melanoma
  1. Combination of ionising radiation with hyperthermia increases the immunogenic potential of B16-F10 melanoma cells in vitro and in vivo. Werthmöller N, Frey B, Rückert M, Lotter M, Fietkau R, Gaipl US. Int J Hyperthermia. 2016;32(1):23-30. doi: 10.3109/02656736.2015.1106011. Epub 2016 Jan 11.

  2. Hyperthermia classic commentary: 'Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology' by J. Overgaard, D. Gonzalez Gonzalez, M.C.C.H. Hulshof, G. Arcangeli, O. Dahl, O. Mella & S.M. Bentzen, International Journal of Hyperthermia 1996;12:3-20. van der Zee J, Overgaard J. Int J Hyperthermia. 2009 Aug;25(5):335-7. doi: 10.1080/02656730902949432

  3. Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicentre randomized trial by the European Society for Hyperthermic Oncology. 1996. Overgaard J, Gonzalez Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Mella O, Bentzen SM. Int J Hyperthermia. 2009 Aug;25(5):323-34. doi: 10.1080/02656730903091986

  4. Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. European Society for Hyperthermic Oncology. Overgaard J, Gonzalez Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Mella O, Bentzen SM. Lancet. 1995 Mar 4;345(8949):540-3

  5. Kim JH, Hahn EW, Ahmed SA. Combination hyperthermia and radiation therapy for malignant melanoma. Cancer 1982; 50 (3): 478-82
Hyperthermia and prostate CA
  1. Franconi C, Vrba J, Micali F, Pesce F. (2011) Prospects for radiofrequency hyperthermia applicator research. I--Pre-optimised prototypes of endocavitary applicators with matching interfaces for prostate hyperplasia and cancer treatments. Int J Hyperthermia. 27(2):187-98.

  2. Masunaga S, Hiraoka M, Akuta K. et al. The phase I/II trial of preoperative thermoradiotherapy in the treatment of urinary bladder cancer. Int J Hyperthermia. 1994;10:31–40.

  3. Yoshida O, Terai A, Shichiri Y, Okada Y, Ishitoya S, Okubo K, Suzuki Y, Arai Y. (1996) Pros-Eight transurethral radiofrequency thermotherapy for benign prostatic hyperplasia: preliminary clinical results. Int J Urol. Nov; 3(6):454-8.

  4. Tilly W, Gellermann J, Graf R et al (2005) Region¬al hyperthermia in conjunction with definitive ra-diotherapy against recurrent or locally advanced prostate cancer
Hyperthermia and pancreatic tumors
  1. Hager ED, Dziambor H, Hoehmann D. Survival and quality of life patients with advanced pancreatic cancer. Proc ASCO. 2002; 21(2357):136b.

  2. Hager ED, Süße B, Popa C. et al. Survival and quality of life of patients with advanced pancreatic cancer. J Cancer Res Clin Oncol. 1994;120(Suppl):R47P10415.

  3. Ishikawa T, Kokura S, Sakamoto N et al (2012) Phase II trial of combined regional hyperthermia and gemcitabine for locally advanced or metastatic pancreatic cancer. Int J Hyperth 28(7):597–604

  4. Maluta S, Schaffer M, Pioli F, Dall’oglio S, Pasetto S, Schaffer PM, Weber B, Giri MG (2011) Regional hyperthermia combined with chemoradiotherapy in primary or recurrent locally advanced pancreatic cancer: an open-label comparative cohort trial. Strahlenther Onkol 187(10):619–62

  5. Mueller-Huebenthal B (2010) Hyperthermia and gemcitabine for the treatment of advanced inoperable pancreatic cancer: a retrospective analysis of 25 cases. Presentation at the 6th binneal conference of Indian Association of Hyperthermia Oncology IAHOM; Jan 2010 Bangalore. (Updated data to be published 2014)

  6. Reiko K, Takeshi I, Kokura S, et al. The inhibitory effect of heat treatment against Epithelial-Mesenchymal Transition (EMT) in human pancreatic adenocarcinoma cell lines. J Clin Biochem Nutr. 2014;55:56–61.

  7. Tschoep-Lechner KE,Milani V, Berger F, Dieterle N, Abdel-Rahman S, Salat C, Issels RD (2013) Gemcitabine and cisplatin combined with regional hyperthermia as second-line treatment in patients with gemcitabine-refractory advanced pancreatic cancer. Int J Hyperth 29(1):8–16

  8. Review: the role of hyperthermia in treating pancreatic tumors. Roesch M, Mueller-Huebenthal B. Indian J Surg Oncol. 2015 Mar;6(1):75-81. doi: 10.1007/s13193-014-0316-5. Epub 2014 May 31. Review.
Hyperthermia in germ cell tumors of children
  1. Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular malignant germ-cell tumours: an open-label, non-randomised, single-institution, phase 2 study.
    Wessalowski R, Schneider DT, Mils O, Friemann V, Kyrillopoulou O, Schaper J, Matuschek C, Rothe K, Leuschner I, Willers R, Schönberger S, Göbel U, Calaminus G; MAKEI study group.
    Lancet Oncol. 2013 Aug;14(9):843-52. doi: 10.1016/S1470-2045(13)70271-7. Epub 2013 Jul 1.

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